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Application of the ‘dual sorption’ model to drug transport through skin
Author(s) -
Chandrasekaran S. K.,
Campbell P. S.,
Watanabe T.
Publication year - 1980
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.760200107
Subject(s) - sorption , transdermal , materials science , lag time , drug , dissolution , molecule , in vivo , dual (grammatical number) , diffusion , thermodynamics , chemical engineering , chemistry , organic chemistry , pharmacology , biological system , adsorption , physics , engineering , medicine , art , microbiology and biotechnology , literature , biology
The dual sorption theory has been extended to the transport of drug molecules through human skin in vitro . By assuming that sorption of drug molecules occurs by both dissolution and binding of drug to immobile sites in the skin, the experimental sorption isotherm can be predicted, and the disparity between steady state and time lag diffusivities can be reconciled. Furthermore, the dual sorption model has been used to develop techniques for controlling these sorption transport processes in order to rapidly achieve predictable transdermal drug delivery in vivo .