Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles | Zendy

do Nascimento Soares Gabriella Onila | Zendy; Ribeiro Lima Machado Raíssa | Zendy; Mendonça Diniz Mariana | Zendy; da Silva Aline Bruna | Zendy

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Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

Author(s) -

do Nascimento Soares Gabriella Onila,

Ribeiro Lima Machado Raíssa,

Mendonça Diniz Mariana,

da Silva Aline Bruna

Publication year - 2020

Publication title -

polymer engineering and science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.503

H-Index - 111

eISSN - 1548-2634

pISSN - 0032-3888

DOI - 10.1002/pen.25549

Subject(s) - nanofiber , crystallinity , cellulose acetate , electrospinning , materials science , differential scanning calorimetry , fourier transform infrared spectroscopy , scanning electron microscope , chemical engineering , controlled release , cellulose , gelatin , amorphous solid , polymer chemistry , nuclear chemistry , polymer , composite material , nanotechnology , organic chemistry , chemistry , physics , engineering , thermodynamics

Novel cellulose acetate (CA) nanofibers incorporated with hormone progesterone (P 4 ) were prepared by electrospinning and its potential as a controlled release system for medicine and veterinary was evaluated by controlled release essay. The morphology, thermal behavior, and structure of P 4 ‐loaded CA nanofibers were characterized by scanning electron microscopy, differential scanning calorimetry, and Fourier‐transform infrared spectroscopy. The analyses revealed that the incorporation of P 4 increased nanofibers' diameter from around 340 to 892 nm to 8% w/w P 4 ‐loaded CA nanofibers. Furthermore, P 4 has demonstrated high interaction with CA affecting its crystalline structure, since pure CA nanofibers presented 67.23% of crystallinity while P 4 ‐loaded CA nanofibers where amorphous. Ultimately, the drug release essay demonstrated a two‐stage profile, and regarding release kinetics, the samples evidenced a diffusion mechanism depending on P 4 concentration in the nanofiber.

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