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Novel strategy for encapsulation and targeted delivery of poorly water‐soluble active substances
Author(s) -
Markovic Maja D.,
Panic Vesna V.,
Seslija Sanja I.,
Milivojevic Ana D.,
Spasojevic Pavle M.,
BoskovicVragolovic Nevenka M.,
Pjanovic Rada V.
Publication year - 2020
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.25448
Subject(s) - solubility , liposome , controlled release , nicotinamide , drug carrier , materials science , caffeine , drug delivery , chemical engineering , chemistry , biophysics , nanotechnology , organic chemistry , medicine , endocrinology , engineering , biology , enzyme
Carriers for targeted delivery and controlled release of poorly water‐soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS—caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.