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A temperature‐responsive polyurethane and its biocompatible and biodegradable nanohydrogels with uniform cross‐linking networks
Author(s) -
Xiao Yao,
Jiang Liang,
Wu Bo,
Liu Zhimeng,
Zhao Yuanyang,
Wang Rui,
Lei Jingxin
Publication year - 2019
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.25151
Subject(s) - materials science , polycaprolactone , polyurethane , polyethylene glycol , chemical engineering , polylactic acid , polymer chemistry , biocompatibility , biodegradation , polymer , composite material , organic chemistry , chemistry , engineering , metallurgy
We prepared a temperature‐responsive polyurethane (PU) with a coil‐to‐globule transition temperature of 36°C in aqueous media, by using polyethylene glycol‐4,000 (PEG‐4000), polycaprolactone diol‐1,000 (PCL‐1000), diphenylmethane diisocyanate‐50, and hydroxyethyl acrylate. Nanohydrogels were synthesized from temperature‐responsive PU through precipitation polymerization without employing a crosslinker. Due to the unique molecular structure of temperature‐responsive PU, PU nanohydrogels have uniform cross‐linking networks resulting in narrow volume phase transition temperature range, showing sensitive temperature responsiveness. Additionally, PEG and PCL segments provide PU nanohydrogels excellent biocompatibility and biodegradability, respectively. POLYM. ENG. SCI., 59:1517–1523 2019. © 2019 Society of Plastics Engineers