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PEG‐based organic–inorganic hybrid coatings prepared by the sol–gel dip‐coating process for biomedical applications
Author(s) -
Catauro Michelina,
Papale Ferdinando,
Piccirillo Giusi,
Bollino Flavia
Publication year - 2017
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.24488
Subject(s) - materials science , biocompatibility , nanocomposite , polymer , polyethylene glycol , coating , osseointegration , peg ratio , chemical engineering , fourier transform infrared spectroscopy , simulated body fluid , sol gel , scanning electron microscope , bioactive glass , composite material , polyethylene , dip coating , titanium , implant , nanotechnology , metallurgy , engineering , medicine , surgery , finance , economics
In the present work, the application of functional coatings on metallic implants was proposed to delay implant failure by improving tissue tolerance and implant osseointegration. Three bioactive and biocompatible organic–inorganic hybrid nanocomposites, consisting of polyethylene glycol (PEG) embedded in a SiO 2 , ZrO 2 , and TiO 2 matrix, respectively, were synthesized via the sol–gel method. Materials in the sol phase were used to dip‐coat titanium grade 4 substrates for use as dental and orthopedic implant models. To investigate the influence of the glass matrix and the polymer amount on the coating structure, and thus on their biological properties, several hybrids were obtained by adding different weight percentages of PEG to each glass matrix. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the presence of the polymer in the nanocomposites and scanning electron microscopy showed that an increase in the PEG content allows crack‐free coatings to be obtained. Moreover, the bioactivity and biocompatibility of both the uncoated and coated titanium implants were investigated and compared by an in vitro test. The results revealed that coated substrates have more enhanced biological performance than the uncoated ones. The bioactivity is not significantly affected by either the inorganic matrix or the PEG amount, whereas the presence of polymer makes the films more biocompatible. POLYM. ENG. SCI., 57:478–484, 2017. © 2017 Society of Plastics Engineers