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Preparation and characterization of pH‐sensitive hydrogel microspheres based on atom transfer radical polymerization
Author(s) -
Zhu HongZheng,
You LiQin,
Wei HongLiang,
Wang GuoFeng,
Chu HuiJuan,
Zhu Jing,
He Juan
Publication year - 2015
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.24168
Subject(s) - atom transfer radical polymerization , materials science , thermogravimetric analysis , ethylene glycol , fourier transform infrared spectroscopy , ethylene glycol dimethacrylate , (hydroxyethyl)methacrylate , polymer chemistry , radical polymerization , chemical engineering , methacrylate , diffusion , emulsion polymerization , polymerization , polymer , composite material , methacrylic acid , thermodynamics , physics , engineering
In this study, we prepared pH‐sensitive hydrogel microspheres by means of atom transfer radical polymerization of hydroxyethyl methacrylate and 4‐vinylpyridine in inverse emulsion, using poly (ethylene glycol) dimethylacrylate as a crosslinker. One‐factor experiment was used to optimize conditions of preparing microspheres and the resulting conditions were presented. The microspheres were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis, scanning electron microscopy, and so forth. The swelling behavior of the as‐prepared microspheres was studied by a classic gravimetric method. Afterward, daidzein was used as a model drug and related release mechanism was investigated. The diffusional coefficients and the corresponding kinetic parameters of chosen mathematical models for fitting drug release were calculated, which indicated drug release accorded with anomalous (non‐Fickian) diffusion mechanism. POLYM. ENG. SCI., 55:2775–2782, 2015. © 2015 Society of Plastics Engineers