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Synthesis, Characterization, and drug release study of acrylamide‐ co ‐itaconic acid based smart hydrogel
Author(s) -
Bera Rabin,
Dey Ayan,
Chakrabarty Debabrata
Publication year - 2015
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.23874
Subject(s) - itaconic acid , self healing hydrogels , swelling , ammonium persulfate , comonomer , acrylamide , materials science , polymer chemistry , drug delivery , chemical engineering , copolymer , aqueous solution , nuclear chemistry , swelling capacity , radical polymerization , polymerization , polymer , chemistry , organic chemistry , nanotechnology , composite material , engineering
A new kind of pH and temperature responsive poly(acrylamide‐ co ‐itaconic acid) hydrogel was prepared by free radical polymerization using ammonium persulfate as initiator and different comonomer ratios. The hydrogels were characterized in terms of chemical composition, swelling‐deswelling behavior, morphology, crystallographic behavior, and drug release properties. All the hydrogels showed high swelling ability in aqueous solutions, the maximum being at pH 7. Swelling decreased on either side of pH 7 (i.e., both in acidic and alkaline region) and increased with increase in temperature. The hydrogel with 10 mol% itaconic acid (IA) absorbed maximum water among the copolymer gels. The cellular structures of the hydrogels were clearly revealed by microscopic analysis and SEM pictures. Swelling of the gels in water followed non‐Fickian type of diffusion principle. The hydrogel was proved to be a controlled release vehicle, for example in drug delivery by using its smart properties. The hydrogel with 10 mol% IA also absorbed maximum amount of drug (ascorbic acid) under study. Incorporation of drug in hydrogel matrix was established from XRD peak analysis. POLYM. ENG. SCI., 55:113–122, 2015. © 2014 Society of Plastics Engineers