Premium
Fabrication of nano/microfiber scaffolds using a combination of rapid prototyping and electrospinning systems
Author(s) -
Park Su A.,
Kim Hyo Joo,
Lee Su Hee,
Lee Jun Hee,
Kim Hyung Keun,
Yoon Taek Rim,
Kim WanDoo
Publication year - 2011
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.21982
Subject(s) - microfiber , electrospinning , materials science , polycaprolactone , biocompatibility , nanofiber , tissue engineering , nanotechnology , fabrication , adhesion , biomedical engineering , scanning electron microscope , rapid prototyping , composite material , polymer , medicine , alternative medicine , pathology , metallurgy
Abstract Tissue‐engineered scaffolds require an adequate three‐dimensional (3‐D) structure for cell growth and attachment. Solid freeform fabrication can provide the interconnected pore to induce the cell ingrowth, and electrospinning technique can make the nanofiber web with high surface for cell attachment. In this study, 3‐D polycaprolactone (PCL) scaffolds were fabricated using a rapid prototyping plotting system coupled with an electrospinning apparatus. Scanning electron micrographs showed that these hybrid scaffolds had a regular microfiber structure with interconnected pores and a nanofiber distribution appropriate for cell attachment. Scaffolds were seeded with MG63 cells for in vitro study and implanted in the tibia of rabbit for in vivo study. The resulting structure also facilitated cell adhesion, proliferation, and differentiation as evidenced by biochemical analyses and confocal microscopy. The hybrid scaffolds also exhibited good biocompatibility and osteoconductivity in animal studies. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers