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Synthesis, characterization, and thermal properties of phosphorylated chitin for biomedical applications
Author(s) -
Jayakumar R.,
Egawa T.,
Furuike T.,
Nair S.V.,
Tamura H.
Publication year - 2009
Publication title -
polymer engineering and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 111
eISSN - 1548-2634
pISSN - 0032-3888
DOI - 10.1002/pen.21306
Subject(s) - chitin , thermogravimetric analysis , biocompatibility , materials science , fourier transform infrared spectroscopy , chemical engineering , nuclear chemistry , polymer chemistry , organic chemistry , chitosan , chemistry , engineering , metallurgy
The present study investigates a suitable material, which is expected to have biocompatibility and to promote tissue regeneration. For this purpose, we have chosen chitin that was chemically modified by phosphorylation with high degree of substitution. The phosphorylated chitin (P‐chitin) was synthesized using the H 3 PO 4 /P 2 O 5 /ET 3 PO 4 /hexanol method. The structure of P‐chitin was analyzed by FTIR, 31 P‐ and 13 C‐NMR spectroscopic studies, scanning electron microscopy, and X‐ray diffraction. The thermal properties of the P‐chitin were also characterized by thermogravimetric analyses. The highly phosphorylated chitin derivatives prepared by this method were soluble in water and amorphous in nature. Thus, H 3 PO 4 /P 2 O 5 /ET 3 PO 4 /hexanol method provides a versatile and alternative route for synthesis of P‐chitin, which would be useful for biomedical applications. POLYM. ENG. SCI., 2009. © 2009 Society of Plastics Engineers