Open AccessDisease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
Author(s) -
Ji Tingting,
Li Xiaodan,
Qiu Yue,
Mei Lin,
Jia Xinbei,
Tai Jun,
Guo Yongli,
Zhang Jie,
Wang Shengcai,
Ni Xin
Publication year - 2021
Publication title -
pediatric investigation
Language(s) - English
Resource type - Journals
ISSN - 2574-2272
DOI - 10.1002/ped4.12247
Subject(s) - obstructive sleep apnea , cognition , medicine , disease , hypoxemia , sleep apnea , affect (linguistics) , excessive daytime sleepiness , sleep (system call) , neuroscience , cardiology , psychology , sleep disorder , psychiatry , communication , operating system , computer science
Obstructive sleep apnea (OSA) is a common sleep‐disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many studies have focused on OSA‐related characteristics, including intermittent hypoxemia and sleep fragmentation. There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction. This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction.