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Treatment patterns and health care costs of mebeverine‐treated IBS patients: a case‐control study
Author(s) -
Goettsch Wim G.,
van den Boom Guido,
BreekveldtPostma Nancy S.,
Smout André J. P. M.,
Herings Ron M. C.
Publication year - 2004
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.997
Subject(s) - medicine , concomitant , laxative , euros , pharmacy , irritable bowel syndrome , constipation , family medicine , philosophy , humanities
Background Irritable bowel syndrome (IBS) is a functional disorder affecting the quality of life of patients. In the Netherlands, mebeverine is currently the only medical treatment registered for IBS, although its efficacy is considered disputable. Objective To assess treatment patterns and associated health care cost in mebeverine users relative to matched controls. Methods A matched case‐control study was performed using pharmacy data. Cases were mebeverine users as proxy for IBS patients. Controls were non‐mebeverine users and matched to cases by age, gender and pharmacy. Prevalence and incidence of mebeverine use, concomitant drug use and hospitalizations were assessed in 3431 cases and 3431 controls. Concomitant drug use and hospitalizations was also assessed in a subgroup of 1222 users of mebeverine and laxatives (proxy for constipation‐IBS) and their controls. Results Twelve per 1000 residents were ever‐dispensed mebeverine in 1998. One‐third of these mebeverine users used laxatives concomitantly. Concomitant drug use and hospitalizations were increased in mebeverine users. The odds ratio for hospitalizations for gastrointestinal reasons was increased predominantly in mebeverine users with concomitant laxative use (OR:8.7; 95%CI [4.3–17.3]). Excess yearly costs for all concomitant medications were €94 [95%CI €79–€109] and for hospital admissions €120 [€74–€166] per mebeverine user. In mebeverine users with concomitant laxative use these costs were €136 and €251 respectively. Conclusions In treated IBS patients, concomitant drug use and hospitalizations are increased relative to matched controls. Medical resource use and associated health care costs are particularly increased in mebeverine users using laxatives. The total mean excess cost per patient per year is €482. Copyright © 2004 John Wiley & Sons, Ltd.