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Breast cancer incidence and use of antihypertensive medication in women
Author(s) -
GonzálezPérez Antonio,
Ronquist Gunnar,
García Rodríguez Luis Alberto
Publication year - 2004
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.910
Subject(s) - medicine , breast cancer , odds ratio , captopril , incidence (geometry) , confidence interval , cancer , cohort study , cohort , pharmacoepidemiology , oncology , logistic regression , rate ratio , gynecology , obstetrics , pharmacology , blood pressure , physics , medical prescription , optics
Purpose Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication. Methods We performed a cohort study with a nested case‐control analysis using the General Practitioner Research Database (GPRD) from the UK. We obtained adjusted estimates by fitting logistic regression models. Results The incidence rate of breast cancer in our cohort of women aged 30–79 years was 156 per 100 000 person‐years. Overall, incidence of breast cancer among users of antihypertensive drugs was no different from the one among non‐users (odds ratio (OR): 1.0; 95% confidence interval (CI): 0.9–1.1). Captopril was not associated with a reduced risk of breast cancer (OR: 0.9; 95%CI: 0.6–1.3). Conclusions We did not find any clear association between antihypertensive drugs and risk of breast cancer. Similarly, captopril was not associated with a reduced risk of breast cancer risk. Copyright © 2003 John Wiley & Sons, Ltd.