Benefit‐risk analysis: a proposal using quantitative methods | Zendy

Holden William L. | Zendy; Juhaeri Juhaeri | Zendy; Dai Wanju | Zendy

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Benefit‐risk analysis: a proposal using quantitative methods

Author(s) -

Holden William L.,

Juhaeri Juhaeri,

Dai Wanju

Publication year - 2003

Publication title -

pharmacoepidemiology and drug safety

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.023

H-Index - 96

eISSN - 1099-1557

pISSN - 1053-8569

DOI - 10.1002/pds.887

Subject(s) - medicine , risk analysis (engineering) , metric (unit) , number needed to treat , risk management , set (abstract data type) , intensive care medicine , actuarial science , operations management , computer science , relative risk , confidence interval , engineering , business , management , economics , programming language

This is the first part of a two‐article series which will introduce the theory and practice of a proposed set of quantitative methods for benefit‐risk analysis. Adjustments to number‐needed‐to‐treat (NNT) analysis and a new method, minimum clinical efficacy (MCE) analysis are presented and critically discussed. The goal of these methods is to condense into a summary metric the benefit‐risk profile of a product so that manufacturers, regulators, clinicians and patients can better understand and participate in risk management. A second article will present examples of these methods. Copyright © 2003 John Wiley & Sons, Ltd.

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