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Health‐related behavior and the use of hormone replacement therapy
Author(s) -
Csizmadi Ilona,
Collet JeanPaul,
Boivin JeanFrançois,
Hanley James A.,
Benedetti Andrea
Publication year - 2004
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.820
Subject(s) - medicine , sigmoidoscopy , hormone replacement therapy (female to male) , colorectal cancer , cancer , population , pharmacoepidemiology , gynecology , colonoscopy , environmental health , pharmacology , medical prescription , testosterone (patch)
Purpose To study health‐related differences between hormone replacement therapy (HRT) users and nonusers among colorectal cases and women without diagnosed cancer. Methods Data from the Saskatchewan Health population‐based databases were used to ascertain the use of HRT, oral contraceptives (OCs), cardiovascular system (CVS) drugs, central nervous system (CNS) drugs, prescribed NSAIDs and vitamins among 3338 women diagnosed with colorectal cancer and 13 025 women without diagnosed cancer. Physician visits and sigmoidoscopy procedures were also determined. Results Among women without diagnosed cancer, HRT was associated with CVS drugs (OR=1.23, 95%CI: 1.10–1.37), CNS drugs (OR=1.96, 95%CI: 1.72–2.23), other hormones (OR=1.12, 95%CI: 1.01–1.24), prescribed vitamins (OR= 1.37, 95%CI: 1.22–1.55), NSAIDs (OR=1.41, 95%CI: 1.18–1.68), having had a sigmoidoscopy 3–5 years prior to index dates (OR=1.33, 95%CI: 1.12–1.59) and 15 or more visits to physicians during the 5th year prior to assigned index date (OR=2.0, 95%CI: 1.77–2.35). Similar results were observed among women diagnosed with colorectal cancer, but HRT use was not associated with having had a sigmoidoscopy. Conclusions Health‐related characteristics of HRT users and nonusers are identified and described. Some of these factors may contribute to selection bias in studies examining the health benefits of HRT. Copyright © 2003 John Wiley & Sons, Ltd.