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Concordance of hospitalizations between Clinical Practice Research Datalink and linked Hospital Episode Statistics among patients treated with oral antidiabetic therapies
Author(s) -
Saine M. Elle,
Carbonari Dena M.,
Newcomb Craig W.,
Gallagher Arlene M.,
Blak Betina T.,
Roy Jason A.,
Wood Jennifer,
Cardillo Serena,
Hennessy Sean,
Strom Brian L.,
Lo Re Vincent
Publication year - 2019
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.4853
Subject(s) - medicine , concordance , clinical practice , emergency medicine , retrospective cohort study , pediatrics , diagnosis code , referral , pharmacoepidemiology , hospital discharge , cohort , family medicine , medical prescription , population , environmental health , pharmacology
Abstract Purpose The ability of the Clinical Practice Research Datalink (CPRD) to ascertain all‐cause hospitalizations remains unknown. We determined the proportion of hospitalizations in CPRD that were also recorded in Hospital Episode Statistics (HES), and vice versa, among patients initiating oral antidiabetic (OAD) therapy. Methods We conducted a retrospective cohort study from October 2009 to September 2012 among OAD‐treated patients registered with general practitioners who contribute to CPRD and consent to HES linkage. In CPRD, we identified initial hospitalizations for each calendar year by an Inpatient Referral, Consultation Type code, or Read code indicating an inpatient episode and determined if an admission date was recorded in HES within ±30 days. We then identified initial HES admission dates and determined if a hospitalization was documented in CPRD within ±30 days. Sensitivity analyses were conducted utilizing HES discharge, rather than admission, dates. Results Among 8574 OAD‐treated HES‐linked patients in CPRD, 6574 initial hospitalizations across the study period were identified in CPRD, and 5188 (78.9% [95% CI, 77.9%‐79.9%]) were confirmed by a HES admission date within ±30 days (median difference, ±3 days [IQR, 1‐7 days]). Among 8609 initial hospital admissions in HES, 4803 (55.7% [95% CI, 54.7%‐56.8%]) hospitalizations were recorded in CPRD within ±30 days (median difference, ±4 days [IQR, 1‐9 days]). Similar results were observed using HES discharge dates. Conclusion A substantial minority of patient‐level hospitalization data are nonconcordant between HES and CPRD. Pharmacoepidemiologic studies within CPRD that seek to identify hospitalizations should consider linkage with HES to ensure adequate ascertainment of inpatient events.