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Concomitant use of calcium channel blockers with dual antiplatelet therapy and re‐hospitalization for acute coronary syndrome
Author(s) -
Wang ChenYu,
Lin ZhenFang,
Lee ChiiMing,
Tsai YiWen,
Huang TingYing,
Shen LiJiuan,
Hsiao FeiYuan
Publication year - 2017
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.4147
Subject(s) - medicine , clopidogrel , concomitant , percutaneous coronary intervention , acute coronary syndrome , guideline , hazard ratio , propensity score matching , cardiology , myocardial infarction , confidence interval , pathology
Background Existing studies suggested that concomitant use of calcium channel blockers (CCBs) may interfere with the antiplatelet effect of clopidogrel. The objective of this study was to examine the effect of concomitant use of CCBs and clopidogrel on risks of acute coronary syndrome (ACS) re‐hospitalization in patients receiving percutaneous coronary intervention. Methods Using the Taiwan National Health Insurance Research Database, we identified 51 925 patients who were admitted for newly diagnosed ACS, received percutaneous coronary intervention, and used clopidogrel within 1 year after discharge. We further stratified them into three groups based on their uses of guideline‐recommended secondary prevention medications for ACS (fully, partially, and non‐compliant groups) to assess the potential modification effect of guideline compliance. For each group, we conducted a 1:1 propensity score matching to minimize selection bias. Cox proportional hazard models were used to investigate the effect of concomitant use of CCBs (overall, subclasses, and individual CCBs) and clopidogrel on risks of ACS re‐hospitalization. Results Concomitant use of CCBs in patients discharged with clopidogrel was significantly associated with a lower risk of ACS re‐hospitalization in the fully compliant group (HR fully compliant = 0.82 [95% confidence interval 0.75–0.89], p < 0.001) but was associated with increased risk of ACS re‐hospitalization in the non‐compliant group (HR non‐compliant = 1.22 [1.03–1.45], p = 0.0252). Conclusions Different guideline compliance of secondary prevention medications could modify the potential drug–drug interaction between clopidogrel and CCBs. Concomitant use of CCBs and clopidogrel was significantly associated with increased risk of ACS re‐hospitalization in ACS patients not compliant to guideline‐recommended secondary prevention drugs. Copyright © 2017 John Wiley & Sons, Ltd.