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Bisphosphonate use and the risk of endometrial cancer: a meta‐analysis of observational studies
Author(s) -
Ou YingJu,
Chiu HuiFen,
Wong YunHong,
Yang YiHsin
Publication year - 2016
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.4075
Subject(s) - medicine , endometrial cancer , bisphosphonate , relative risk , odds ratio , cochrane library , incidence (geometry) , meta analysis , cohort study , absolute risk reduction , oncology , cancer , gynecology , confidence interval , osteoporosis , physics , optics
Abstract Background The association of bisphosphonate use and the risk of endometrial cancer is still unclear. No meta‐analysis was conducted to review the evidence concerning this topic. Methods Relevant studies were identified through PubMed and EMBASE and the Cochrane Library databases. The adjusted relative risk (RR) or odds ratios were determined using a fixed effects or random effects model, depending on the overall heterogeneity. Results Seven studies, including four cohort studies and three case–control studies, met the method criteria and were included. The random effects model showed a significant reduction in the risk association between bisphosphonate use and endometrial cancer incidence (RR 0.75, 95%CI 0.60–0.94, p = 0.064, I 2 = 49.6%). A significantly protective effect was observed with the use of bisphosphonate for more than 1 year, and we found a statistically significant risk reduction with the use of bisphosphonate for more than 1 to 3 years (RR 0.58, 95%CI 0.47–0.72) and for more than 3 years (RR 0.44, 95%CI 0.28–0.70). However, with the use of bisphosphonate for less than 1 year (RR 0.92, 95%CI 0.64–1.34), we found no protective effect against endometrial cancer. Conclusions We found that the use of bisphosphonate was significantly associated with a 25% risk reduction in the incidence of endometrial cancer in the overall analysis. Furthermore, the use of bisphosphonate for more than 1 year but not less than 1 year may have a more beneficial effect on endometrial cancer risk. Copyright © 2016 John Wiley & Sons, Ltd.