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Patterns and prevalence of medication use across the menstrual cycle among healthy, reproductive aged women
Author(s) -
Johnson Kristen A.,
Sjaarda Lindsey A.,
Mumford Sunni L.,
Garbose Rebecca A.,
Schliep Karen C.,
Mattison Donald,
Perkins Neil J.,
WactawskiWende Jean,
Schisterman Enrique F.
Publication year - 2016
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.3993
Subject(s) - medicine , menstrual cycle , medical prescription , amoxicillin , antibiotics , ibuprofen , over the counter , hormone , pharmacology , microbiology and biotechnology , biology
Purpose The purpose of this study is to characterize the patterns of medication intake in healthy, reproductive‐age women not using hormonal contraception. Methods Two hundered fifty‐nine healthy, premenopausal women (18–44 years of age) enrolled in the BioCycle Study (2005–2007) were followed over two menstrual cycles. Women were excluded if they were currently using oral contraceptives or other chronic medications. Over‐the‐counter and prescription medication use among participants was evaluated daily throughout the study via a diary assessing type of medication, dosage, units, and frequency. Medications were categorized as allergy, antibiotics, central nervous system (CNS), cold and cough, gastrointestinal, musculoskeletal, and pain medication based on primary active ingredient. Medication use within each category was assessed across standardized 28‐day cycles to evaluate differences in use across cycle phases (i.e., early, middle, and late). Results Medication use was reported by 73% of participants. The most and least frequently used medications, respectively, were pain (69%) and musculoskeletal medications (1%). Pain, CNS, and antibiotic medication use varied significantly across the cycle, with pain and CNS medication more frequently reported during menses and antibiotics more frequently during the luteal phase. Allergy, cold and cough, gastrointestinal, and musculoskeletal medication use did not vary across the cycle. Conclusions Patterns of medication use among reproductive age women vary across the menstrual cycle for certain types of medications, particularly in pain (e.g., Ibuprofen), antibiotics (e,g, Amoxicillin), and CNS (e.g., Adderall) medications. Future studies involving use of these types of medication in premenopausal women may need to consider the relationship of their use to the menstrual cycle. Copyright © 2016 John Wiley & Sons, Ltd.

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