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Abstracts
Author(s) -
Hao Wang,
Maria Loane,
Ester Garne,
Joan K. Morris,
Vera Nelen,
Babak Khoshnood,
Anke Rißmann,
Awi Wiesel,
Mary O’Mahony,
Anna Pierini,
Elisa Calzolari,
Miriam Gatt,
Marian K. Bakker,
MarieClaude Addor,
David Tucker,
Kari Klungsøyr,
Anna LatosBieleńska,
Jan P. Mejnartowicz,
Karin Källén,
Ingeborg Barišić,
Christine VerellenDumoulin,
Bérénice Doray,
Larraitz Arriola,
Diana Wellesley,
Amanda J. Neville,
Lolkje Theodora Wilhelmina de Jong-van den Berg,
Helen Dolk
Publication year - 2014
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.3701
Subject(s) - pharmacoepidemiology , medicine , citation , library science , family medicine , information retrieval , pharmacology , computer science , medical prescription
Background: Lower Urinary Tract Symptoms (LUTS) are a significant health issue for the elderly yet little is known about the clinical relevance of anticholinergic medication use on urinary function. Objectives: To explore the relationship between anticholinergic burden and urinary outcomes (LUTS) in a cohort of community dwelling older men. Methods: A cross sectional survey of baseline data from a longitudinal cohort of 1705 men aged over 70 years resident in the Sydney metropolitan area was conducted. Medication use (prescription and non prescription) and urinary outcomes data (frequency, nocturia, incontinence, post-void residual (PVR) volume, overall LUTS severity and urinary quality of life (UQoL)) was collected during scheduled clinic visits. Anticholinergic burden was assessed using 4 scales (Anticholinergic Cognitive Burden scale (ACB), Anticholinergic Drug burden Scale (ADS), Anticholinergic Risk Scale (ARS), Anticholinergic component of the Drug Burden Index (DBI-A)). Ordinal regression with adjusted parameter estimates was used to compare urinary outcomes with each scale. Results: The mean participant age was 76.9 (±5.5) years. Most participants were using at least one medication. With the exception of the ADS and the ACB (κ = 0.629) agreement between scales to categorize anticholinergic burden was poor (