Premium
Impact of cancer‐related fatigue on chemotherapy‐induced nausea and vomiting in Asian cancer patients
Author(s) -
Poon Ken Shing Ho,
Un Man Kit,
Low Xiu Hui,
Cheung Yin Ting,
Yap Kevin YiLwern,
Chan Alexandre
Publication year - 2013
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.3516
Subject(s) - medicine , nausea , interquartile range , vomiting , chemotherapy induced nausea and vomiting , confounding , odds ratio , chemotherapy , cancer , antiemetic
Cancer‐related fatigue (CRF) has been suggested to be associated with the occurrence of chemotherapy‐induced nausea and vomiting (CINV). This study aims to evaluate the potential of CRF in predicting the occurrence of CINV. Method This is a prospective, observational study. Recruited patients received moderately to highly emetogenic single‐day chemotherapy regimens. On the day of chemotherapy, patients were instructed to provide a score (Likert scale of 0–10) to describe how CRF interfered with his or her ability to engage in daily activities and a score for how severe it was. Patients were then given a standardized 5‐day diary to document their CINV events. Results A total of 473 eligible patients (median age: 55 years, interquartile range (IQR): 48–61 years) were recruited, with most of the patients diagnosed with gastrointestinal (45%) and breast (37%) cancers. The median score of fatigue interference was 3 (IQR: 0–5). After confounders were adjusted for, patients with low fatigue interference scores (≤3) were more likely to achieve complete protection (no nausea, no vomiting, and no breakthrough antiemetics) of CINV (adjusted odds ratio = 1.57, 95%CI [1.05, 2.35], p = 0.027). Conclusion This is the largest study to date to evaluate the association between CRF and CINV. Patients experiencing CRF possessed a higher risk of poor control for CINV. Copyright © 2013 John Wiley & Sons, Ltd.