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Agreement between patients' self‐report and medical records for vaccination: the PGRx database
Author(s) -
GrimaldiBensouda Lamiae,
Aubrun Elodie,
Leighton Pamela,
Benichou Jacques,
Rossignol Michel,
Abenhaim Lucien
Publication year - 2013
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.3401
Subject(s) - medicine , concordance , vaccination , pharmacoepidemiology , medical record , medical prescription , medical diagnosis , database , family medicine , pediatrics , immunology , pathology , computer science , pharmacology
ABSTRACT Purpose Patients' self‐reported vaccine exposure (PS) may be subject to memory errors and other biases. Physicians' prescription records and other medical records (MR) do not capture noncompliance with vaccination. This study compared PS with MR for influenza, 23‐valent pneumococcal, and human papillomavirus (HPV) vaccines. Methods The Pharmacoepidemiologic General Research Extension (PGRx) database uses a network of over 300 general practitioners across France, who systematically recruit an age‐ and sex‐stratified sample of patients (≥ 14 years old), without reference to their diagnoses or prescriptions. Patients received a structured telephone interview, combined with an interview guide listing vaccines commonly given. Patients' self‐reported vaccination in the 3 years before their recruitment was compared with medical records kept by the physician or the patient. Results Concordance between PS and MR was assessed for 7613 patients for whom both sources of information were available. Agreement within 3 years before the recruitment date was substantial for influenza vaccines (prevalence and bias‐adjusted kappa [PABAK] = 0.74, sensitivity PS relative to MR 81.5%) and high for 23‐valent pneumococcal vaccines (PABAK = 0.98, sensitivity PS 49.6) and HPV vaccines (PABAK = 0.92, sensitivity PS 91.6). In adjusted analyses, agreement varied with sociodemographic and health‐related factors, particularly for influenza and 23‐valent pneumococcal vaccines. Conclusions The PGRx method for drug exposure assessment is a new tool in pharmacoepidemiology that shows substantial to high agreement between PS and MR for exposure to various vaccines. Our finding of high agreement between PS and MR for HPV vaccination status in young women is a significant addition to the literature. Copyright © 2013 John Wiley & Sons, Ltd.