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Uses of proton pump inhibitors and hypomagnesemia
Author(s) -
Gau JenTzer,
Yang YuXiao,
Chen Roger,
Kao TzuCheg
Publication year - 2012
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.3224
Subject(s) - hypomagnesemia , medicine , confounding , proton pump inhibitor , gastroenterology , logistic regression , magnesium , population , materials science , environmental health , metallurgy
Purpose Hypomagnesemia associated with proton pump inhibitor (PPI) therapy has been documented in case reports. We performed a cross‐sectional study to examine the association between PPI use and serum magnesium (Mg) levels or hypomagnesemia. Methods Data were extracted from hospitalized adults with basic metabolic panels and/or serum magnesium levels available during the hospital stays. The first Mg value was used for data analysis. Hypomagnesemia is defined as levels less than 1.7 mg/dL (or 0.70 mmol/L). Multiple linear and logistic regression analyses were used to assess the association between PPI use and Mg levels or hypomagnesemia, respectively. Results Among study patients, PPI users ( n = 207) had a mean Mg level of 1.91[SD = 0.34] mg/dL, and non‐users ( n = 280) 2.00 (0.30) mg/dL, p = 0.004. PPI use was associated with lower serum Mg levels (adjusted coefficient β = −0.10, 95%CI = [−0.16, −0.04]) after adjusting for confounders. PPI use was associated with risk of hypomagnesemia after adjusting for confounders (adjusted OR = 2.50, 95%CI = [1.43, 4.36]). Both standard (1) and high (2 or higher) defined daily dose units of PPI therapy were associated with hypomagnesemia. Conclusions PPI use was associated with lower serum Mg levels and hypomagnesemia in a population of hospitalized adult patients. Our study supports the general notion that long‐term PPI use could be associated with sub‐clinical Mg insufficiency or deficiency status. Copyright © 2012 John Wiley & Sons, Ltd.