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Drug‐induced acute pancreatitis
Author(s) -
Bergholm U.,
Langman M.,
Rawllins M.,
Gaist D.,
Andersen M.,
Edwards I. R.,
Wiholm B.E.
Publication year - 1995
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.2630040603
Subject(s) - medicine , acute pancreatitis , pancreatitis , etiology , intensive care medicine , adverse effect , incidence (geometry) , adverse drug reaction , drug , pharmacology , physics , optics
Abstract The incidence of acute pancreatitis appears to have increased in the USA, Denmark and in the United Kingdom and one suggested explanatory factor is a simultaneously increased use of certain drugs. This report surveys the available information on the association between drugs and acute pancreatitis in the literature and in spontaneous reporting systems in Denmark, Sweden and in the United Kingdom, supplemented with information from the WHO data base. Apart from one case‐control study which provided evidence for an association between diuretic use and acute pancreatitis, the information in the literature is based on single case reports. About 15 drugs are frequently reported both in literature, and in spontaneous reporting systems, to be associated with pancreatitis and can be regarded as adverse reaction signals. The validity of such data is often low and does not provide information on relative or absolute risks, if any, for a drug adverse reaction association. To elucidate the possible role of drugs in etiology of acute pancreatitis, further formal epidemiologic studies are needed.