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Drug‐induced allergic hepatitis
Author(s) -
Tsutsui Hiroko,
Sakagami Chihiro,
Hasegawa Itaru
Publication year - 1993
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.2630020704
Subject(s) - medicine , immunology , eosinophilia , cholestasis , drug , hepatitis , liver disease , antigen , hepatitis c , disease , hepatitis b , pharmacology , pathology
Abstract Drug‐induced allergic hepatitis is a tissue‐specific inflammatory disease caused by hypersensitivity to a particular drug, accompanied by a systemic allergic reaction such as eosinophilia. Although the frequency of drug‐induced allergic hepatitis appears to be increasing in proportion to the diversity of available drugs, the precise mechanism by which tissue specific injury occurs still remains to be elucidated. In this review, we present our recent data on the involvement of an abnormal immune response to a newly formed antigen composed of the causal drug and host liver specific protein (LSP), a liver‐specific autoantigen, as a directing antigen to causing the liver specificity, and the relationship between overproduction of IL‐5 and peripheral blood eosinophilia. In addition, we describe a cholestatic factor, produced by CD4 + T lymphocytes responding abnormally to the causal drug plus LSP, which is involved in the intrahepatic cholestasis frequently associated with this disease.