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Captopril‐induced lichen planus pemphigoides
Author(s) -
Ben Salem Chaker,
Chenguel Lilia,
Ghariani Najet,
Denguezli Mohamed,
Hmouda Houssem,
Bouraoui Kamel
Publication year - 2008
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.1618
Subject(s) - captopril , medicine , bullous pemphigoid , dermatology , immunology , antibody , blood pressure
Purpose To report a rare case of lichen planus pemphigoides (LPP) possibly induced by captopril. Case summary A 74‐year‐old woman developed pruriginous and bullous lichenoid eruption after starting captopril for hypertension. Histopathological and immunological features were consistent with the diagnosis of LPP that was managed by discontinuing captopril and corticosteroid therapy. Eight months after the cessation of oral steroid therapy, no relapse had occurred. Discussion LPP, a rare skin disorder, has been generally considered to represent a mixture of clinical, histopathological and immunological patterns of lichen planus and bullous pemphigoid. It is predominantly idiopathic. However, in rare cases it has been associated with the administration of drugs. Here we present a typical LPP related to the use of captopril. Conclusions Clinicians should be aware of the ability of captopril to induce LPP. Copyright © 2008 John Wiley & Sons, Ltd.