Clozapine‐related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment | Zendy

Manfredi Roberto | Zendy; Sabbatani Sergio | Zendy

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Clozapine‐related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment

Author(s) -

Manfredi Roberto,

Sabbatani Sergio

Publication year - 2007

Publication title -

pharmacoepidemiology and drug safety

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.023

H-Index - 96

eISSN - 1099-1557

pISSN - 1053-8569

DOI - 10.1002/pds.1476

Subject(s) - medicine , antimicrobial , clozapine , adverse effect , intensive care medicine , empiric therapy , pediatrics , psychiatry , alternative medicine , schizophrenia (object oriented programming) , chemistry , organic chemistry , pathology

An exemplary case report of a patient who developed an unpredictable sudden, late‐onset clozapine‐related life‐threatening agranulocytosis expressed by a nadir of 14 polymorphonuclear cells/µL, and subsequently underwent protective hospitalisation and broad spectrum, empiric antimicrobial therapy and also experienced serious intolerance to a number of administered antibiotic and antifungal agents, is reported and discussed on the grounds of the available evidence from the literature. Copyright © 2007 John Wiley & Sons, Ltd.

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