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The CADEUS study: methods and logistics
Author(s) -
Depont F.,
Fourrier A.,
Merlière Y.,
Droz C.,
Amouretti M.,
Bégaud B.,
Bénichou J.,
Moride Y.,
Blin P.,
Moore N.
Publication year - 2007
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/pds.1348
Subject(s) - medicine , pharmacoepidemiology , respondent , rofecoxib , cohort , celecoxib , cohort study , health care , family medicine , national health insurance , database , emergency medicine , pediatrics , pharmacology , population , environmental health , biochemistry , chemistry , political science , medical prescription , cyclooxygenase , law , economics , enzyme , economic growth , computer science
Purpose At the request of the French Health authorities, a study called CADEUS ( C OX‐2 inhibitors and NS A IDs: de scription of us ers) aimed to describe the users of cyclo‐oxygenase (COX)‐2 inhibitors and traditional non‐selective non‐steroidal anti‐inflammatory drugs (tNSAIDs). We report here the methodology, logistics and study design performances. Methods CADEUS is a cohort study designed to include 40 000 patients randomly sampled monthly in the French National Healthcare Insurance database, who received at least one dispensation of celecoxib, rofecoxib or tNSAIDs (1:1:2), from September 2003 to August 2004. Patients and prescribers were asked to fill a questionnaire on indication, medical history, risk factors and hospitalizations since drug acquisition. There was no reminder. For each respondent, healthcare resources used for the 6 months before and after inclusion were extracted from the database. Response rate, response delay, responders and non‐responders characteristics were assessed. Results Of the 222 879 patients and their prescribers contacted, 20.8% patients and 32.6% prescribers responded. Median response delay was 16 days for patients and 17 days for physicians. Factors associated with patient response were age, cohort, type of prescriber and period of inclusion. Conclusion This is the first study of this design in France, combining data from a claims database and direct patient and prescriber questionnaires. Copyright © 2006 John Wiley & Sons, Ltd.