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Corneal confocal microscopy: potential usage in the context of diabetes mellitus
Author(s) -
Bondugulapati LN Rao,
Narayen Nitesh
Publication year - 2021
Publication title -
practical diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.205
H-Index - 24
eISSN - 2047-2900
pISSN - 2047-2897
DOI - 10.1002/pdi.2328
Subject(s) - medicine , diabetes mellitus , context (archaeology) , disease , confocal microscopy , peripheral neuropathy , intensive care medicine , surgery , pathology , endocrinology , paleontology , microbiology and biotechnology , biology
Diabetic peripheral neuropathy (DPN) is a difficult diagnosis to make, especially in its early stages. Standard practice has been to take judicious clinical history and examination with 10gm monofilament, which not only misses the early disease but also lacks the ability to detect small fibre neuropathy. Given the morbidity, mortality, as well as the cost implications diabetic foot ulcer disease has, it is crucial to diagnose DPN early to prevent the complications associated with it. Here, we discuss the utility of corneal confocal microscopy as a potential tool for early diagnosis of DPN, quantify its severity, and assess therapeutic benefit to identify nerve fibre repair in the context of disease modifying treatments of DPN. Copyright © 2021 John Wiley & Sons.