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The impact of dapagliflozin on HbA 1c , systolic blood pressure and weight: a review of dapagliflozin use in a Scottish city
Author(s) -
Kueh Christopher JL,
Connelly Paul,
Harte Rachael,
Smith Christopher,
Boyle James G
Publication year - 2017
Publication title -
practical diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.205
H-Index - 24
eISSN - 2047-2900
pISSN - 2047-2897
DOI - 10.1002/pdi.2100
Subject(s) - dapagliflozin , medicine , blood pressure , diabetes mellitus , type 2 diabetes , urinary system , population , cohort , urology , endocrinology , environmental health
We aimed to determine the efficacy of dapagliflozin in the management of type 2 diabetes in a Scottish population through measurements of glycaemic control, blood pressure and weight. Dapagliflozin was effective in improving HbA 1c by 10 mmol/mol ( SE 1.8, p < 0.001), systolic blood pressure by 9. 8mmHg ( SE 2.2, p < 0.001) and weight by 3.2 kg ( SE 0.6, p < 0.001). There was a significant proportion of people with diabetes who reported side effects with dapagliflozin relating to genital and urinary tract infections. Dapagliflozin appears to be an effective drug in improving HbA 1c , systolic blood pressure and weight in people with type 2 diabetes. However, in this cohort a substantial proportion of people with diabetes did not tolerate this drug due to side effects. Copyright © 2017 John Wiley & Sons.