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Prenatal evaluation of fetal renal function based on serum beta 2 ‐microglobulin assessment
Author(s) -
Ciardelli Valentina,
Rizzo Nicola,
Farina Antonio,
Vitarelli Marisa,
Boni Paola,
Bovicelli Luciano
Publication year - 2001
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.90
Subject(s) - fetus , medicine , urinary system , beta 2 microglobulin , gestational age , renal function , kidney , gestation , endocrinology , urology , pregnancy , biology , genetics
The relationship between fetal renal function (FRF) and fetal serum beta 2 ‐microglobulin (B2MG) was investigated by comparing its value in 112 unaffected fetuses with that of 23 fetuses presenting with urinary tract malformations (UTM). Fetal serum level of B2MG was totally unrelated to gestational age; its value increased in cases of severe impairment of FRF but was similar to controls in all mild uropathies ( p <0.05). Evaluating serum B2MG could be beneficial in fetuses with severe renal damage, but is of no use in unilateral UTM since only the global FRF is tested and not the function of each single kidney. Copyright © 2001 John Wiley & Sons, Ltd.