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Prenatal diagnosis of congenital Chagas' disease (American trypanosomiasis)
Author(s) -
Okumura Maria,
Aparecida dos Santos Vera,
Camargo Mário E.,
Schultz Regina,
Zugaib Marcelo
Publication year - 2004
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.813
Subject(s) - chagas disease , medicine , fetus , in utero , anemia , pregnancy , trypanosoma cruzi , gestation , trypanosomiasis , prenatal diagnosis , myocarditis , obstetrics , pathology , immunology , biology , parasite hosting , world wide web , computer science , genetics
The prenatal diagnosis of congenital transmission of Chagas' disease in a pregnant woman with the indeterminate form of the disease is reported. Sonography revealed fetal hydrops at 31 weeks' gestation. Anti‐ Trypanosoma cruzi IgM and IgG antibodies were negative in the fetal blood sampled by cordocentesis, but T. cruzi trypomastigotes were found in its buffy coat. Owing to anemia, in utero exchange transfusion was undertaken, but fetal demise ensued. Labor was induced and a stillborn infant weighing 2030 g was delivered. The pathological examination revealed placentitis and meningoencephalitis, myocarditis and splenitis in the stillborn fetus. Amastigotes were found in the myocardium, brain and placenta. Copyright © 2004 John Wiley & Sons, Ltd.