Premium
Mid‐gestation Down syndrome screening test and pregnancy outcome among unstimulated assisted‐conception pregnancies
Author(s) -
Shulman Adrian,
Maymon Ron
Publication year - 2003
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.650
Subject(s) - gestation , medicine , pregnancy , gynecology , obstetrics , embryo transfer , fetus , embryo , trisomy , biology , genetics , microbiology and biotechnology
Objectives Alteration of mid‐gestation serum markers in assisted‐conception pregnancies is believed to be attributable to ovarian superovulation treatment modalities. We compared alpha‐fetoprotein (AFP), human chorionic gonadotrophin (hCG), and unconjugated estriol (uE 3 ) in two groups of unstimulated assisted‐conception pregnancies, that is, own‐oocyte frozen embryos (own‐FET) versus oocyte‐donated (OD) embryos. Methods Forty‐three OD‐conceived and 31 own‐FET‐conceived singleton parturient women (aged 29 ± 4 years and 31 ± 4 years respectively, P < 0.05) were followed from embryo transfer throughout pregnancy. Results The daily pattern of first‐trimester serum β‐hCG was similar in both groups. The OD group had only significantly increased AFP concentrations compared to the own‐FET group (1.38 vs 0.99 median MoM respectively, P = 0.002). Although there were no chromosomal abnormalities and no fetal or neonatal deaths in either group, 12% OD women and 6.5% own‐FET women were found screen‐positive. Eight OD women and 11 FET women had an adverse obstetric outcome ( P = NS). Conclusion OD embryos are a unique clinical model for evaluating the uterine compartment and its contribution to mid‐gestation serum marker secretion. Copyright © 2003 John Wiley & Sons, Ltd.