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Antenatal findings and early postnatal outcomes in pregnancies with trisomy 21: a 10 year retrospective review at a tertiary centre
Author(s) -
Stott Daniel,
Dos Santos Francois,
Rodgers Anna,
Holgado Elaine,
Pandya Pranav P.
Publication year - 2022
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.6215
Subject(s) - medicine , obstetrics , caesarean section , trisomy , pregnancy , intrauterine growth restriction , fetus , pediatrics , prenatal diagnosis , percentile , retrospective cohort study , surgery , statistics , genetics , mathematics , biology
Objective To examine the antenatal imaging features, intrapartum findings and early postpartum course of pregnancies with trisomy 21 (T21) at a tertiary hospital in the United Kingdom. Methods Women with pregnancies diagnosed with T21 on antenatal or post‐mortem/postnatal karyotyping, from February 2010–2020. Outcome measures included antenatal imaging findings, fetal growth restriction (FGR), birthweight, mode of delivery and early neonatal outcomes. Results 76 women were included. There were six intrauterine deaths and 70 livebirths. Thirty‐eight (50%) had an antenatal diagnosis and twenty‐five (33%) had a suspected diagnosis but declined further testing. The diagnosis was unanticipated in 13 (17%). Cardiac anomalies (35.5%) were the most common antenatal anomaly. Doppler abnormalities were apparent in 48/73 (68%). Eighteen (25.7%) had antenatal FGR. The majority were delivered by Caesarean section, and 21.4% of babies weighed