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Vertical transmission of SARS‐CoV2 during pregnancy: A high‐risk cohort
Author(s) -
Maeda Mariane de Fátima Yukie,
Brizot Maria de Lourdes,
Gibelli Maria Augusta Bento Cicaroni,
Ibidi Silvia Maria,
Carvalho Werther Brunow de,
Hoshida Mara Sandra,
Machado Clarisse Martins,
Sabino Ester Cerdeira,
Oliveira da Silva Lea Campos de,
Jaenisch Thomas,
MendesCorrea Maria Cássia Jacintho,
Mayaud Philippe,
Francisco Rossana Pulcinelli Vieira
Publication year - 2021
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5980
Subject(s) - medicine , pregnancy , cord blood , viremia , colostrum , obstetrics , transmission (telecommunications) , risk factor , amniotic fluid , umbilical cord , covid-19 , cohort , cohort study , immunology , fetus , human immunodeficiency virus (hiv) , disease , biology , genetics , antibody , infectious disease (medical specialty) , electrical engineering , engineering
Objective Identify the potential for and risk factors of SARS‐CoV‐2 vertical transmission. Methods Symptomatic pregnant women with COVID‐19 diagnosis in whom PCR for SARS‐CoV‐2 was performed at delivery using maternal serum and at least one of the biological samples: cord blood (CB), amniotic fluid (AF), colostrum and/or oropharyngeal swab (OPS) of the neonate. The association of parameters with maternal, AF and/or CB positivity and the influence of SARS‐CoV‐2 positivity in AF and/or CB on neonatal outcomes were investigated. Results Overall 73.4% (80/109) were admitted in hospital due to COVID‐19, 22.9% needed intensive care and there were four maternal deaths. Positive RT‐PCR for SARS‐CoV‐2 was observed in 14.7% of maternal blood, 13.9% of AF, 6.7% of CB, 2.1% of colostrum and 3.7% of OPS samples. The interval between COVID‐19 symptoms and delivery was inversely associated with SARS‐CoV‐2 positivity in the maternal blood ( p = 0.002) and in the AF and/or CB ( p = 0.049). Maternal viremia was associated with positivity for SARS‐CoV‐2 in AF and/or CB ( p = 0.001). SARS‐CoV‐2 positivity in the compartments was not associated with neonatal outcomes. Conclusion Vertical transmission is possible in pregnant women with COVID‐19 and a shorter interval between maternal symptoms and delivery is an influencing factor.