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Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta
Author(s) -
Kunpalin Yada,
Deprest Jan,
Papastefanou Ioannis,
Bredaki Emma,
Sacco Adalina,
Russo Francesca,
Richter Jute,
Jansen Katrien,
Ourselin Sebastien,
De Coppi Paolo,
David Anna L.,
Ushakov Fred,
De Catte Luc
Publication year - 2021
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5945
Subject(s) - splenium , rostrum , corpus callosum , fetus , medicine , spina bifida , gestational age , anatomy , agenesis , lesion , agenesis of the corpus callosum , fetal head , exencephaly , pathology , surgery , biology , pregnancy , radiology , magnetic resonance imaging , white matter , teratology , botany , genetics , genus
Objective To determine the incidence and characterise corpus callosum (CC) abnormalities in fetuses with spina bifida aperta (SBA) between 18 and 26 weeks of gestation. Methods This was a retrospective study on fetuses with isolated SBA and who were assessed for fetal surgery. Digitally stored ultrasound images of the brain were reviewed for the presence/absence of the CC, and the length and diameter of its constituent parts (rostrum, genu, body and splenium). We used regression analysis to determine the relationship between CC abnormalities and gestational age, head circumference, ventricle size, lesion level and lesion type. Results Nearly three‐quarters of fetuses with isolated SBA had an abnormal CC (71.7%, 76/106). Partial agenesis was most common in the splenium (18.9%, 20/106) and the rostrum (13.2%, 14/106). The most common abnormal pattern was of a short CC with normal diameter throughout. Of note, 20.8% (22/106) had a hypoplastic genu and 28.3% (30/106) had a thick body part. Larger lateral ventricle size was associated with partial agenesis of the CC (odds ratio [OR]: 0.14, p < 0.001) and inversely associated with a shorter CC (OR: 2.60, p < 0.01). Conclusion An abnormal CC is common in fetuses with isolated SBA who are referred for fetal surgery.