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Origins and mechanisms leading to aneuploidy in human eggs
Author(s) -
Wartosch Lena,
Schindler Karen,
Schuh Melina,
Gruhn Jennifer R.,
Hoffmann Eva R.,
McCoy Rajiv C.,
Xing Jinchuan
Publication year - 2021
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5927
Subject(s) - aneuploidy , biology , infertility , chromosome , cytogenetics , chromosome segregation , genetics , advanced maternal age , andrology , pregnancy , fetus , medicine , gene
The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.