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Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology‐related complications
Author(s) -
Krispin Eyal,
Kushnir Anya,
Shemer Asaf,
Rienstein Shlomit,
Berkenstadt Michal,
Yi Yoav,
Weisz Boaz
Publication year - 2021
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5896
Subject(s) - nuchal translucency , medicine , anatomical pathology , obstetrics , nuchal translucency measurement , aneuploidy , pathology , pregnancy , fetus , prenatal diagnosis , biology , genetics , immunohistochemistry , gene , chromosome
Objective Identify placental pathology‐related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis. Methods A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3 mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013–2019) in a single tertiary academic center. The following placental pathology‐related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity. Results A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental‐related complications frequencies were higher in the study group , with a composite rate of 17.02% versus 6.52% in controls ( p = 0.042%). Secondary outcomes did not differ between groups. Conclusions Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental‐related complications.