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Fetal dural sinus thrombosis: A systematic review
Author(s) -
Sacco Adalina,
Pannu Deepika,
Ushakov Fred,
Dyet Leigh,
Pandya Pranav
Publication year - 2021
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5869
Subject(s) - medicine , pregnancy , coagulopathy , gestational age , neurocognitive , in utero , pediatrics , fetus , obstetrics , gestation , thrombosis , surgery , genetics , cognition , psychiatry , biology
Fetal dural sinus thrombosis (DST) is a rare condition. Although numerous case reports exist, the findings appear heterogenous and providing accurate patient counselling remains challenging. Methods A systematic literature review was conducted in accordance with PRISMA guidance. Results Thirty‐one studies including 78 patients were included in this review. No association with maternal or neonatal coagulopathy, infection or trauma was found. The average gestational age at diagnosis was 25 weeks (range 17–34 weeks). Approximately half of foetuses affected were female (48.7%); one quarter were male (25.6%) and one quarter had no sex stated (25.6%). Termination of pregnancy was chosen in 25.6% of cases (20/78). In continuing pregnancies,10.3% (6/58) experienced a perinatal death. Antenatally, the majority of lesions either decreased in size (38.5%) or completely resolved (32.7%). The neonatal or childhood outcome was normal in 88.0% of survivors (44/50). The average age at follow up was 16.4 months, ranging from birth to 6 years. Conclusion This review found that 10% of DST cases experience in‐utero or neonatal death. In survivors, the majority of cases reduce in size or completely resolve in pregnancy and 85% are reported to have a good outcome. However, further evidence is needed regarding long‐term neurocognitive sequelae.