Premium
Obstetric and perinatal outcomes in cases of congenital Zika syndrome
Author(s) -
Melo Adriana,
de Sales Tavares Jousilene,
de Assis Costa Marianny,
Santana de Aguiar Renato,
Malinger Gustavo,
de Oliveira Melo Fabiana,
Balbino daSilva Mariana,
Luiz Fonseca SchamberReis Bruno,
Gama Gabriela,
Tanuri Amilcar,
Chimelli Leila,
OliveiraSzejnfeld Patricia,
M. Ramos de Amorim Melania
Publication year - 2020
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5831
Subject(s) - microcephaly , medicine , ventriculomegaly , zika virus , pregnancy , obstetrics , umbilical cord , pediatrics , oligohydramnios , gestational age , arthrogryposis , prenatal diagnosis , amniotic fluid , retrospective cohort study , fetus , surgery , virus , anatomy , virology , biology , genetics
Objective To describe obstetric and perinatal outcomes in cases of congenital Zika syndrome (CZS). Methods A dual prospective and retrospective cohort study involving 102 pairs of mothers and fetuses/children with CZS whose infection was confirmed by testing for the Zika virus in amniotic fluid, umbilical cord blood, and fragments from the placenta of the newborn infant (confirmed CZS), or by intrauterine imaging tests (neurosonography), and/or postnatal computed tomography (presumed CZS). Results Suspicion of CZS was investigated by ultrasonography during pregnancy in 52.9% of cases. The principal prenatal imaging findings were ventriculomegaly (43.1%) and microcephaly (42.2%). Median gestational age at delivery was 39 weeks, with 15.7% being premature. Mean head circumference at birth was 30.0 ± 2.3 cm, with 66% of cases being classified as having microcephaly. Arthrogryposis was found in 10 cases (9.8%). There were no fetal deaths; however, nine neonatal deaths were recorded, and three autopsies were performed. Conclusion Neonatal mortality was high, almost 10%. Regarding the abnormalities of CZS, microcephaly, although common, was not present in all cases and intracranial findings need to be taken into consideration for diagnosis. Therefore, ultrasound screening during pregnancy should be systematized and expanded in endemic zones.