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Identification and management of congenital parvovirus B19 infection
Author(s) -
Attwood Lucy O.,
Holmes Natasha E.,
Hui Lisa
Publication year - 2020
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5819
Subject(s) - hydrops fetalis , medicine , parvovirus , erythema infectiosum , pregnancy , fetus , amniocentesis , seroconversion , obstetrics , gestation , pediatrics , prenatal diagnosis , immunology , parvoviridae , human immunodeficiency virus (hiv) , biology , virus , genetics
Parvovirus B19 (B19V) infection is well known for its mild, self‐limiting clinical presentations in children, such as erythema infectiosum. Approximately 40% of women of childbearing age are susceptible to B19V infection. While maternal B19V infection usually has a good prognosis , B19V can cause severe fetal anaemia and pregnancy loss due to its ability to suppress erythroid progenitor cells. Non‐invasive ultrasound monitoring for fetal anaemia is usually performed if maternal seroconversion occurs in the first 20 weeks of gestation, with amniocentesis for fetal infection reserved for those who first present with fetal anaemia or hydrops of unknown cause. Intrauterine transfusion is the standard treatment for severe fetal anaemia and is associated with a significant improvement in survival. However, survivors of hydrops fetalis may have a higher rate of long‐term neurodevelopmental complications compared with non‐hydropic survivors. This review aims to synthesise published data on the diagnosis, surveillance and outcomes of congenital parvovirus infection to assist clinicians in diagnosing and managing this important condition.