Premium
Ultrasound features of fetal toxoplasmosis: A contemporary multicenter survey in 88 fetuses
Author(s) -
Codaccioni Camille,
Picone Olivier,
Lambert Véronique,
Maurice Paul,
Pomar Léo,
Winer Norbert,
Guibaud Laurent,
Lavergne RoseAnne,
Saliou AnneHélène,
Quinio Dorothée,
Benachi Alexandra,
Noel Catherine,
Ville Yves,
Cuillier Fabrice,
Pomares Christelle,
Ferret Nicole,
Filisetti Denis,
Weingertner AnneSophie,
VequeauGoua Valérie,
Cateau Estelle,
Benoist Guillaume,
Wallon Martine,
Dommergues Marc,
Villena Isabelle,
Mandelbrot Laurent
Publication year - 2020
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5756
Subject(s) - medicine , toxoplasmosis , ultrasound , fetus , seroconversion , gestational age , pregnancy , obstetrics , serology , pediatrics , radiology , pathology , virus , biology , antibody , immunology , genetics , virology
Objective To describe the lesions detected by prenatal ultrasound examination in congenital toxoplasmosis (CT). Methods We retrospectively analyzed all cases of fetal infection with Toxoplasma gondii with ultrasound anomalies described by fetal medicine experts in 2009 to 2019 in 30 French centers. Results Eighty‐eight cases of CT were included. Forty‐five (51.1%) had one or more cerebral signs only, 35 (39.8%) had cerebral plus extracerebral signs and 8 (9.1%) had extracerebral signs only. The main cerebral signs were intracranial hyperechogenic nodular foci (n = 60) of which 20 were isolated, ventriculomegalies (n = 44) which generally increased during follow‐up, and periventricular abscesses (n = 12). The main extracerebral signs were hepatomegaly and/or splenomegaly (n = 14), small for gestational age (n = 14), ascites (n = 14, including 2 with hydrops), and hyperechogenic bowel (n = 11). Maternal infection occurred mostly in the first or second trimester (81 cases), periconceptionally in one and in the third trimester in six cases. The first ultrasound signs were detected after a median of 7 weeks (range: 1.4; 24.0) following maternal toxoplasmosis seroconversion. Conclusion While no sign was specific of CT, there were typical associations of cerebral signs with or without extracerebral signs. Detailed ultrasound examination could improve prognostic evaluation, as well as diagnosis of CT in settings lacking serological screening.