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Prenatal testing in pregnancies conceived by in vitro fertilization with pre‐implantation genetic testing
Author(s) -
Arian Sara E.,
Erfani Hadi,
Westerfield Lauren E.,
Buffie Alexandra,
Nassef Salma,
Gibbons William E.,
Van den Veyver Ignatia B.
Publication year - 2020
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5711
Subject(s) - medicine , obstetrics , aneuploidy , genetic testing , in vitro fertilisation , pregnancy , exact test , genetic counseling , gynecology , prenatal diagnosis , population , fetus , biology , genetics , chromosome , environmental health , gene
Objective Women with pregnancies resulting from in vitro fertilization (IVF) with normal pre‐implantation genetic testing for aneuploidy (PGT‐A) are advised to undergo prenatal screening and testing during pregnancy. It is not well known how many follow these recommendations. Our objective was to study prenatal testing decisions made by women with pregnancies conceived through IVF with PGT‐A. Methods We performed a retrospective review of women who received genetic counseling during pregnancies conceived through IVF with normal PGT‐A. We excluded those who received genetic counseling preconceptionally prior to IVF. Statistical analysis included descriptive statistics and after testing for normality by the Kolmogorov‐Smirnov test, independent t test, Mann‐Whitney U test, or Chi‐square/Fisher's exact test. Results Data from 83 women were included. Of these, 53 (63.9%) had at least one of the following prenatal tests: first trimester combined screening (16.9%), non‐invasive prenatal screening (NIPS) (45.8%), second trimester serum screening (6%), and invasive diagnostic testing (6%). 10.8% had more than one of the above tests and 36.1% declined all tests. Conclusion Almost two‐thirds of women who were pregnant after IVF with normal PGT‐A had prenatal aneuploidy screening or testing. Future prospective studies with larger cohorts are needed to further ascertain decision making in this population.