Premium
Midtrimester triple‐test levels in women with chronic hypertension and altered renal function
Author(s) -
Shenhav Simon,
Gemer Ofer,
Sherman Dan J.,
Peled Ronit,
Segal Shmuel
Publication year - 2003
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.564
Subject(s) - medicine , renal function , triple test , gestation , chronic hypertension , creatinine , endocrinology , pregnancy , urology , obstetrics , fetus , biology , genetics
Objective To study the association between midtrimester triple‐test levels and renal function in pregnant women with chronic hypertension. Methods Forty‐three patients with chronic hypertension for whom renal function was evaluated by the creatinine clearance test between 14‐ and 20‐weeks gestation were studied. Midtrimester triple‐test values obtained as part of Down screening program were correlated with renal function. Results hCG correlated inversely with creatinine clearance ( r = −0.345; p = 0.002) and directly with alpha‐fetoprotein ( r = 0.499; p = 0.003). Conclusions In pregnant women with chronic hypertension, impaired renal function may alter midtrimester maternal serum hCG levels. Copyright © 2003 John Wiley & Sons, Ltd.