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Analysis of PGT‐M and PGT‐SR outcomes at a Canadian fertility clinic
Author(s) -
Butler Rachel,
Nakhuda Gary,
Guimond Colleen,
Jing Chen,
Lee Nora,
Hitkari Jason,
Tallon Niamh,
Taylor Beth,
Yuzpe Albert
Publication year - 2019
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5496
Subject(s) - pregnancy , medicine , in vitro fertilisation , pregnancy rate , embryo transfer , gynecology , genetic testing , obstetrics , fertility , genetic counseling , insemination , embryo , retrospective cohort study , artificial insemination , reproductive medicine , biology , genetics , population , environmental health
Objective Outcomes from in vitro fertilization (IVF)/intrauterine insemination (ICSI) cycles for patients who underwent preimplantation genetic testing for monogenic/single gene (PGT‐M) and structural chromosome rearrangements (PGT‐SR) patients were reviewed. Patients pursuing PGT‐M and PGT‐SR often do not have pre‐existing fertility issues and therefore may have uncertain expectations of successful outcomes. Before pursuing PGT‐M and PGT‐SR, patients require evidence‐based counseling regarding the probability of having a healthy child. Method Retrospective review from a single private IVF clinic of 73 PGT patients, from whom a total of 437 blastocysts were biopsied and screened. Embryo results and pregnancy outcomes were analyzed. Results Of the 45 PGT‐M patients, 64.4% had at least one euploid unaffected embryo. The cumulative pregnancy rate for patients who had embryo transfers in this group was 89.7%, with an ongoing pregnancy or delivery rate of 48.9%. For the 28 PGT‐SR patients, 60.7% had at least one euploid unaffected embryo. The cumulative pregnancy rate for patients who had embryo transfers in this group was 87.5%, with an ongoing pregnancy or delivery rate of 42.9%. Conclusion This information can supplement the existing data in the literature to counsel new patients in terms of realistic expectations of success following PGT‐M and PGT‐SR.