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Clinical value of prenatal MRI for diagnosis of isolated ventriculomegaly and prediction of early postnatal developmental outcomes
Author(s) -
Li Zhi,
Lv Yidan,
He Pingya,
Luo Zhiqin,
Pan Liming,
Du Ying,
Fang Rong,
Liu Yuqin,
Li Lan,
Zhu Ling
Publication year - 2019
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5399
Subject(s) - ventriculomegaly , medicine , subgroup analysis , ventricle , fetus , pediatrics , cardiology , pregnancy , confidence interval , biology , genetics
Objective To investigate the relationship of ventriculomegaly (VM) with postnatal neurological development. Methods Fetuses with isolated VM on MRI ( n = 160; VM group) were separated into three subgroups according to lateral ventricle width: subgroup A (10.0‐12.0 mm; n = 113), subgroup B (12.1‐15.0 mm; n = 37), and subgroup C (>15.0 mm; n = 10). Fifty normal fetuses formed a control group. Post‐delivery changes in ventricular width and neurological development were assessed with MRI/ultrasonography and the Gesell Development Schedules (GDS), respectively, at 3, 6, 12, and 18 months. Results GDS scores of subgroup A and subgroup B did not differ from that of the controls at 3 and 6 months. Subgroup B scores differed significantly from the control scores at 12 and 18 months. Subgroup C scores differed from the control scores at all‐time points (all P < 0.05). In the VM group, GDS scores at 12 and 18 months were significantly different from the scores at 3 months, and the score at 18 months was significantly different from the score at 6 months ( P < 0.05 for all). Conclusion The milder the VM, the more likely it was to disappear or improve in the postnatal period. However, specific postnatal rehabilitation should be considered when fetal ventricular width is greater than 12.1 mm.