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Prenatal diagnosis and clinical implications of an apparently isolated right aortic arch
Author(s) -
Vigneswaran Trisha V.,
Allan Lindsey,
Charakida Marietta,
Durward Andrew,
Simpson John M.,
Nicolaides Kypros H.,
Zidere Vita
Publication year - 2018
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5388
Subject(s) - medicine , asymptomatic , aortic arch , prenatal diagnosis , context (archaeology) , incidence (geometry) , vascular ring , bronchoscopy , pediatrics , genetic testing , fetus , obstetrics , aorta , surgery , pregnancy , paleontology , physics , biology , optics , genetics
What is already known about the topic? Right aortic arch (RAA) has an association with extracardiac and chromosomal anomalies. RAA with left arterial duct can form a vascular ring. In children with RAA, there is poor correlation of symptoms and tracheal compression. What does this study add? The majority of prenatal cases of an isolated RAA in our cohort are identified during routine screening. Microdeletion of chromosome 22q11 is the most common genetic association with an apparently isolated RAA, it is seen in a minimum of 7% of cases. A chromosomal or genetic anomaly is found in half of fetuses with RAA and increased nuchal translucency thickness (NT) and in one‐fifth of those with normal NT.