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Urine biochemistry to predict long‐term outcomes in fetuses with posterior urethral valves
Author(s) -
Dreux Sophie,
Rosenblatt Jonathan,
MoussyDurandy Amélie,
Patin Franck,
Favre Romain,
LortatJacob Stephen,
El Ghoneimi Alaa,
Oury JeanFrançois,
Deschenes Georges,
Ville Yves,
Heidet Laurence,
Muller Francoise
Publication year - 2018
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5359
Subject(s) - urinary system , medicine , fetus , urine , prenatal diagnosis , renal function , cohort , multivariate analysis , posterior urethral valve , urology , urinary tract obstruction , cohort study , predictive value , obstetrics , pregnancy , biology , genetics
What's already known about this topic? In fetuses with lower urinary tract obstruction, prenatal counseling with regard to long‐term renal function is an unmet challenge. The literature on the predictive value of fetal urine analysis is controversial. What does this study add? In a cohort of 89 children affected by posterior urethral valves, and who reached 10 years of age, multivariate analysis of fetal urinary markers predicted renal function with 93% sensitivity and 71% specificity.