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Interfering effect of maternal cell contamination on invasive prenatal molecular genetic testing
Author(s) -
Koczok Katalin,
Gombos Éva,
Madar László,
Török Olga,
Balogh István
Publication year - 2018
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5319
Subject(s) - pyrosequencing , sanger sequencing , multiplex ligation dependent probe amplification , genotyping , multiplex , massive parallel sequencing , dna sequencing , biology , computational biology , genetics , genotype , dna , gene , exon
What is already known about this topic? Analytical sensitivity of the studied molecular genetic methods such as Sanger DNA sequencing, multiplex ligation‐dependent probe amplification, and next‐generation sequencing has been studied previously in relation to somatic mosaicism testing. What does this study add? We determine significant maternal cell contamination levels for these molecular genetic techniques in a comprehensive way and also evaluate previously published data in the context of maternal cell contamination and prenatal molecular testing.