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Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring
Author(s) -
Sun Kun,
Lun Fiona M.F.,
Leung Tak Y.,
Chiu Rossa W.K.,
Lo Y.M. Dennis,
Sun Hao
Publication year - 2018
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5214
Subject(s) - dna methylation , cpg site , fetus , methylation , cell free fetal dna , placenta , biology , computational biology , bioinformatics , computer science , pregnancy , prenatal diagnosis , dna , genetics , gene , gene expression
During human pregnancy, the DNA methylation of placental tissue is highly relevant to the normal growth and development of the fetus; therefore, methylomic analysis of the placental tissue possesses high research and clinical value in prenatal testing and monitoring. Thus, our aim is to develop an approach for reconstruction of the placental methylome, which should be completely noninvasive and achieve high accuracy and resolution.