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Maternal liver transplant: Another cause of discordant fetal sex determination using cell‐free DNA
Author(s) -
Neofytou Maria,
Brison Nathalie,
Van den Bogaert Kris,
Dehaspe Luc,
Devriendt Koen,
Geerts Anja,
Vermeesch Joris R.
Publication year - 2018
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.5194
Subject(s) - cell free fetal dna , fetus , medicine , pregnancy , obstetrics , liver transplantation , organ transplantation , prenatal diagnosis , gynecology , andrology , transplantation , biology , surgery , genetics
Noninvasive prenatal testing (NIPT) can very accurately determine fetal sex during pregnancy. We present an exceptional case where NIPT contradicts the ultrasound‐based sex determination. The pregnant woman was recipient of a liver transplant from a male donor. Graft‐derived cell‐free DNA released into the maternal circulation clouded the NIPT‐based sex determination. Hence, NIPT is not advisable when the pregnant mother underwent an organ transplant.